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Charles Mok suggests that combining semaglutide with specific probiotics and a Mediterranean diet can boost weight loss

Phase 3 Results (REIMAGINE-2, Feb 2026): HbA1c reduction of up to 1.91 points, outperforming semaglutide alone Weight loss of up to 14.2% at 68 weeks in adults with type 2 diabetes and obesity In weight-management evaluation, diabetics achieved ~15.7% weight loss vs 3.1% with placebo Regulatory update: Novo Nordisk filed for FDA approval (Dec 2025) for weight management, supported by the REDEFINE clinical program

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Finally, a total of three eligible articles were included in the systematic review, and overall GLP-1RA reduces the incidence of DR compared with existing glucose-lowering agents, but more research is required to verify the generalisability of the findings

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